CurePSP • August 9th, 2016

Progressive Supranuclear Palsy | PSP | Learn More

Why has no one heard of PSP? PSP is rare: no one even realized it existed until 1963, when several patients were first described at a national neurology research convention and the disease was given its name. In retrospect, at least 12 cases of PSP had appeared in the medical literature between 1909 and 1962, but because of its resemblance to Parkinson’s, it wasn’t recognized as a distinct disease. The brain under the microscope is almost identical to that of “post-encephalitic parkinsonism,” a

PubMed Central (PMC) • September 4th, 2023

Stability properties of neuronal microtubules

"The neuron is an extraordinary cell. In all of nature, it is the cell whose exaggerated morphology is most intimately related to its unique functions and challenges. A typical vertebrate neuron consists of a small soma (situated in the brain, spinal cord, or peripheral ganglion), several dendrites, and a single elongated axon. The axon is specialized to transmit information, while the dendrites form a receptive field for incoming information. The axon is effectively unlimited in its growth poten

PubMed Central (PMC) • September 4th, 2023

Natural products as a rich source of tau-targeting drugs for Alzheimer’s disease

"Few permeability studies have been conducted on the natural products discussed above. However, curcumin (4) was found effective at crossing the BBB [85]. Other tau-reducing polyphenols of the proanthocyanidin and flavonoid classes may be good candidates for AD leads as a result of having similar chemical character to curcumin".

PubMed Central (PMC) • September 4th, 2023

Natural polyphenols effects on protein aggregates in Alzheimer's and Parkinson's prion-like diseases

In plants, polyphenols (or phenolic compounds) play an essential role, in protection from ultraviolet radiation and against aggression by pathogens or predators, contribute to their colour and flavour and facilitate growth and reproduction. To date, more than 8000 natural polyphenols have been identified in plants (Pandey and Rizvi, 2009). They may be grouped into classes according to the shared structural characteristics of their carbon skeletons. The main classes include phenolic acids and der

PubMed Central (PMC) • September 3rd, 2023

EGCG impedes human Tau aggregation and interacts with Tau

"EGCG inhibits Tau aggregation by forming intermediate Tau aggregates and disintegrating them. The intermediate aggregates formed are non-toxic to neuronal cells. On the other hand, when matured Tau fibrils are treated with EGCG, they are disaggregated and cleared".

Perk Energy • August 20th, 2019

Ingredient Spotlight: What is (and what isn't) EGCG?

EGCG and the other catechins (antioxidants) comprise between 30-40% of the water-soluble solids in green tea and is often credited for the many health-promoting attributes associated with it. Though EGCG is predominantly found in green tea, it also is present in many other foods, such as cranberries, strawberries, blackberries, kiwis, cherries, pears, peaches, apples, avocados, pecans, pistachios, and hazelnuts. Dark chocolate and legumes offer these polyphenolic compounds as well.

Healthline • April 26th, 2019

EGCG (Epigallocatechin Gallate): Benefits, Dosage, and Safety

Formally known as epigallocatechin gallate, EGCG is a type of plant-based compound called catechin. Catechins may be further categorized into a larger group of plant compounds known as polyphenols. EGCG and other related catechins act as potent antioxidants that may protect against cellular damage caused by free radicals ( ). Free radicals are highly reactive particles formed in your body that can damage your cells when their numbers get too high. Eating foods high in antioxidants like catec

LIVESTRONG.COM • June 8th, 2010

4 Foods That Quell Inflammation, Thanks to This Superstar Ingredient | Livestrong.com

"Curcumin, the substance responsible for the golden color in turmeric, is known as an anti-inflammatory superstar".